OBJECTIVE: To study retrospectively the effect and ADRs of etretinate in 49 patients of keratinization, including psoriasis 33 cases, pityriasis rubra pilaris 6 cases, ichthyosis 3 cases and lichen planus 7 cases. 目的:回顾性研究了依曲替酯治疗49例角化性疾病(银屑病33例,毛发红糠疹6例,鱼鳞病3例和扁平苔藓7例)的疗效及不良反应等。